Influenza Virus Transcription

New Anti-Influenza Agents: Targeting the Virus Entry and Genome Transcription

Introduction: The emergence and spread of the pandemic H1N1 influenza virus in 2009 indicates a limitation in the strategy to control the infection, despite a long-established vaccination programme and approved antivirals. Production the proper vaccine against influenza is difficult due to the genetic recombination of virus in the event of pandemic and co-circulation of drug-resistance variants...

Transcription and replication of influenza virus RNA.

The Influenza viruses are among the most dangerous human pathogens, since they have a wide animal reservoir and re-emerge continuously in the human population. They constitute a collection of highly variable pathogens that cause respiratory infections in man. Influenza type A viruses contain a segmented genome composed by 8 RNA molecules of negative polarity. Each one replicates and transcribe ...

A Reverse transcription-PCR assay for detection of type A influenza virus and differentiation of avian H7 subtype

Abstract : Avian influenza virus (AIV) infection is a major cause of influenza mortality in birds and can cause human mortality and morbidity. Although the risk of infection with avian influenza virus (AIV) is generally low for most people, the pathogenic virus can cross the species barrier and acquires the ability to infect and be transmitted among the human population; therefore the ra...

2009 H1N1 Influenza Virus Seroepidemiology

Mutational analysis of influenza B virus RNA transcription in vitro.

The roles of the 3'- and 5'-terminal nucleotides and the panhandle structure of influenza B virus virion RNA were analyzed in vitro by transcription of model RNA templates with influenza B virus RNA polymerase. The results suggest that the stability of the panhandle and breathing of the extreme ends of the panhandle are important factors for efficient transcription. Influenza B virus polymerase...